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PUBLICATIONS

NEW IN PRESS I Huhn & Ho et al., Mar 2025

Journal of the American Society (JACS) 2025

eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses

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NEW IN PRESS I Khayenko et al., 2025

eLife 2025

Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site

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2025

Huhn C, Ho SY, ..., Hell J, Maric HM. eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses; Journal of the American Chemical Society (JACS). Article ASAP; DOI: 10.1021/jacs.5c00772

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Talucci I, ..., Maric HM. Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies; bioRxiv, 2025.02. 26.640323

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V Khayenko, C Makbul, C Schulte, N Hemmelmann, S Kachler, B Böttcher, HM Maric. Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site; eLife; 13: RP98827; DOI: 10.7554/eLife.98827.2​

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G Danti, L Popella, J Vogel, HM Maric. High-Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics, in review​

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2024

Lützenkirchen FP et al.; Neurobeachin regulates receptor downscaling at GABAergic inhibitory synapses in a protein kinase A-dependent manner; Communications Biology 7 (1), 1-14

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Kostrz D et al Competition between glycine and GABAA receptors for gephyrin controls their equilibrium populations at inhibitory synapses; bioRxiv, 2024.12. 09.627587

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Uhl et al. RNA-mediated MYC multimerization suppresses innate immune signaling; bioRxiv, 2024.12. 06.627168

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Yeste‐Vázquez A et al. Structure‐Based Design of Bicyclic Helical Peptides That Target the Oncogene β‐Catenin; Angewandte Chemie 136 (47), e202411749

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Navarro S, Talucci I et al. The humanized platelet glycoprotein VI Fab inhibitor EMA601 protects from arterial thrombosis and ischaemic stroke in mice; European Heart Journal 45 (43), 4582-4597

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Reissland M et al.; USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer; Oncogene, 1-15

 

Talucci I, Maric HM; Epitope landscape in autoimmune neurological disease and beyond; Trends in Pharmacological Sciences

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Fernandes EFA et al. Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain; Journal of Medicinal Chemistry 67 (14), 11975-11988

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D Papadopoulos et al. The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex; Molecular Cell 84 (11), 2070-2086. e20

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Wirths O et al. Amino‐terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains; Neuropathology and Applied Neurobiology 50 (3), e12991

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Talucci et al. Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity; Frontiers in immunology 15, 1329013

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Rauber S et al. CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis; Nature Immunology 25 (4), 682-692

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Arlt FA et al KCNA2 IgG autoimmunity in neuropsychiatric diseases; Brain, Behavior, and Immunity 117, 399-411

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Jessen M et al. Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers; Oncogene 43 (8), 578-593

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Kreissner KO, Faller B, Talucci I, Maric HM. MARTin—an open-source platform for microarray analysis; Frontiers in Bioinformatics 4, 1329062

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Wiessler AL, Talucci I et al. Glycine receptor β–targeting autoantibodies contribute to the pathology of autoimmune diseases; Neurology: Neuroimmunology & Neuroinflammation 11 (2), e200187

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2023

Bünger I, Talucci I et al. Synapsin autoantibodies during pregnancy are associated with fetal abnormalities. Brain, behavior, & immunity-health 33, 1006785


Rauber S et al. Pro-resolving remodelling of the mesenchymal network during resolution of arthritis detected by FAP PET-imaging, EUROPEAN JOURNAL OF IMMUNOLOGY 2023, 53, 284-284


Papadopoulos et al. Direct RNA-binding by MYCN mediates feedback from RNA processing to transcription control, bioRxiv, 2023.08. 16.553474


Xavier da Silva TN, Schulte C, Alves AN, Maric HM, Friedmann Angeli JP. Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules, Cell Death & Disease 14 (4), 281 33    2023


Rauber et al. Molecular imaging with fibroblast activation protein tracers depicts inflammatory joint damage and its transition to resolution of inflammation; bioRxiv, 2023.01. 17.5244254   2023


Jobin ML et al. Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane; Nature communications 14 (1), 34

2022

Schulte C, Soldà A, Spänig S, Adams N, Bekić I, Streicher W, Heider D, Strasser R, Maric HM. Multivalent binding kinetics resolved by fluorescence proximity sensing. Commun Biol. 2022 Oct 7;5(1):1070. doi: 10.1038/s42003-022-03997-3.

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Khayenko V, Schulte C, Reis SL, Avraham O, Schietroma C, Worschech R, Nordblom NF, Kachler S, Villmann C, Heinze KG, Schlosser A,  Schueler-Furman O, Tovote P, Specht CG, Maric HM. A Versatile Synthetic Affinity Probe Reveals Inhibitory Synapse Ultrastructure and Brain Connectivity. Angew Chem Int Ed Engl. 2022 Apr 14:e202202078. doi: 10.1002/anie.202202078

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Schulte C, Khayenko V, Maric HM. Peptide Microarray-Based Protein Interaction Studies Across Affinity Ranges: Enzyme Stalling, Cross-Linking, Depletion, and Neutralization. Methods Mol Biol. 2023;2578:143-159. doi: 10.1007/978-1-0716-2732-7_10.

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Dos Reis R, Kornobis E, Pereira A, Tores F, Carrasco J, Gautier C, Jahannault-Talignani C, Nitschké P, Muchardt C, Schlosser A, Maric HM, Ango F, Allemand E. Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity. Nat Commun. 2022 Jun 18; 13: 3507. doi: 10.1038/s41467-022-31264-w­

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Talucci I, Maric HM. Peptide Microarrays for Studying Autoantibodies in Neurological Disease. Methods Mol Biol. 2023;2578:17-25. doi: 10.1007/978-1-0716-2732-7_2.

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Solvie D, ..., Maric, et al MYC multimers shield stalled replication forks from RNA polymerase. Nature 612 (7938), 148-155

 

Kaufmann J, ..., Schulte C, Maric HM. et al. A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening; Communications Biology 5 (1), 1206

2021

Schulte C, Khayenko V, Gupta AJ, Maric HM. Low-cost synthesis of peptide libraries and their use for binding studies via temperature-related intensity change. STAR Protoc. 2021 Jun 15;2(3):100605. doi: 10.1016/j.xpro.2021.100605.

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Khayenko V, Maric HM. Innovative affinitätsbasierte Markierungen für die High-End-Mikroskopie. BIOspektrum. 2021 Jul 27, 709-712. doi: 10.1007/s12268-021-1672-7.

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Makbul C, Khayenko V, Maric HM, Böttcher B. Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype. Microorganisms. 2021 Apr 29;9(5):956. doi: 10.3390/microorganisms9050956.

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Schulte C and Maric HM. Expanding GABA(A)R pharmacology via receptor-associated proteins. Curr Opin Pharmacol, 56 (2021). 57:98-106. doi:10.1016/j.coph.2021.01.004.

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Bartling CRO, Jensen TMT, Henry SM, Colliander AL, Sereikaite V, Wenzler M, Jain P, Maric HM, Harpsøe K, Pedersen SW, Clemmensen LS, Haugaard-Kedström LM, Gloriam DE, Ho A, Strømgaard K. Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. J Am Chem Soc. 2021 Jan 20;143(2):891-901. doi: 10.1021/jacs.0c10696.

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Moreno-Yruela C, Bæk M, Vrsanova AE, Schulte C, Maric HM*, Olsen CA*. Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases. Nat Commun. 2021 Jan 4;12(1):62. doi: 10.1038/s41467-020-20250-9.

(*shared corresponding authors)

2020

Schulte C, Khayenko V, Nordblom NF, Tippel F, Peck V, Gupta AJ, Maric HM. High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale. iScience. 2020 Dec 7;24(1):101898. doi: 10.1016/j.isci.2020.101898.

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Gründl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP, Gaubatz S. Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. PLoS Genet. 2020 May 29;16(5):e1008818. doi: 10.1371/journal.pgen.1008818.

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Langlhofer G, Schaefer N, Maric HM, Keramidas A, Zhang Y, Baumann P, Blum R, Breitinger U, Strømgaard K, Schlosser A, Kessels MM, Koch D, Qualmann B, Breitinger HG, Lynch JW, Villmann C. A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition. J Neurosci. 2020 Jun 17;40(25):4954-4969. doi: 10.1523/JNEUROSCI.2490-19.2020.

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Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M,  Diefenbacher ME. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med. 2020 Apr 7;12(4):e11101. doi: 10.15252/emmm.201911101.

2019

Sereikaite V, Fritzius T, Kasaragod VB, Bader N, Maric HM, Schindelin H, Bettler B, Strømgaard K. Targeting the γ-Aminobutyric Acid Type B Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain Containing Proteins/GABAB Receptor Protein-Protein Interaction. J Med Chem. 2019 Oct 10;62(19):8819-8830. doi: 10.1021/acs.jmedchem.9b01087.

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Khayenko V, Maric HM. Targeting GABA(A)R-Associated Proteins: New Modulators, Labels and Concepts. Front Mol Neurosci. 2019 Jun 26;12:162. doi: 10.3389/fnmol.2019.00162.

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Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 2019 Jun;51(6):990-998. doi: 10.1038/s41588-019-0413-z.

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Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E. MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031.

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Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H. Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins. Neuron. 2019 Feb 20;101(4):673-689.e11. doi: 10.1016/j.neuron.2019.01.001.

2016 - 2011

Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Neuron. 2016 Oct 5;92(1):126-142. doi: 10.1016/j.neuron.2016.08.035.

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Maric HM*, Kasaragod VB*, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H. Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors  through gephyrin. Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767.

(* shared first authorship)

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Maric HM, Kasaragod VB, Haugaard-Kedström L, Hausrat TJ, Kneussel M, Schindelin H, Strømgaard K. Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors. Angew Chem Int Ed Engl. 2015 Jan 7;54(2):490-4. doi: 10.1002/anie.201409043.

 

Maric HM, Kasaragod VB, Schindelin H. Modulation of gephyrin-glycine receptor affinity by multivalency. ACS Chem Biol. 2014 Nov 21;9(11):2554-62. doi: 10.1021/cb500303a.

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Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ. Gephyrin, the enigmatic organizer at GABAergic synapses. Front Cell Neurosci. 2012 May 15;6:23. doi: 0.3389/fncel.2012.00023.

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Maric HM, Mukherjee J, Tretter V, Moss SJ, Schindelin H. Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site. J Biol  Chem. 2011 Dec 9;286(49):42105-14. doi: 10.1074/jbc.M111.303412.

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Mukherjee J, Kretschmannova K*, Gouzer G*, Maric HM*, Ramsden S, Tretter V, Harvey K, Davies PA, Triller A, Schindelin H, Moss SJ. The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin. J Neurosci. 2011 Oct 12;31(41):14677-87. doi: 10.1523/JNEUROSCI.2001-11.2011.

(*shared second authorship)

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Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, Harvey K. Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin. J Biol Chem. 2011 Oct 28;286(43):37702-11. doi: 10.1074/jbc.M111.291336.

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